A mouse model for Costello syndrome reveals an Ang II–mediated hypertensive condition
J. Clin. Invest. Alberto J. Schuhmacher, et al. 118:2169 doi:10.1172/JCI34385 [Go to this article.]

Figure 3
Mammary gland hyperplasia in H-Ras^G12V virgin female mice. Red carmine whole-mount staining (A–C) and H&E staining of paraffin sections (D–F) of mammary glands of H-Ras^+/+ (A and D), H-Ras^+/G12V (B and E), and H-Ras^G12V/G12V (C and F) mice. Insets show representative detail. Mammary glands of H-Ras^G12V/G12V mice displayed substantial white fat atrophy, greater ductal-lobulillar development (arrowheads), and ductal ectasia (asterisk). Scale bars: 1 mm (A–C); 10 μm (D–F).